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Article

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

Pflugers Archiv : European journal of physiology - 1 Apr 2024

White Bobby, Swietach Pawel

Abstract excerpt

Acidosis is a chemical signature of the tumour microenvironment that challenges intracellular pH homeostasis. The orchestrated activity of acid-base transporters of the solute-linked carrier (SLC) family is critical for removing the end-products of fermentative metabolism (lactate/H+) and maintaining a favourably alkaline cytoplasm. Given the critical role of pH homeostasis in enabling cellular activities,...

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Identifiers

PMID: 37999800
DOI: 10.1007/s00424-023-02876-y
PMCID: PMC11006749

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