Trem2 regulates macrophage phenotype via the JAK2/STAT3 signaling pathway to ameliorate ventricular remodeling after acute myocardial infarction.

doi:10.1007/s11033-026-12622-z

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Article

Trem2 regulates macrophage phenotype via the JAK2/STAT3 signaling pathway to ameliorate ventricular remodeling after acute myocardial infarction.

Molecular biology reports - 27 Aug 2026

He Zefeng, Feng Jing, Yan Ru, Wu Peng, Zhu Baozhen, Li Huifang, Yang Taoyu, Lu Yaxin, He Baotong, Ma Xueping, Jia Shaobin, Cong Guangzhi

Abstract excerpt

BACKGROUND: Pathological ventricular remodeling after acute myocardial infarction (AMI) is a critical pathological basis of heart failure, with macrophages as the core driver of inflammatory imbalance. Trem2-expressing macrophages regulate inflammation resolution and tissue repair, and the JAK2/STAT3 pathway is involved in macrophage phenotype modulation. However, whether Trem2 regulates macrophage polarization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42658285
DOI: 10.1007/s11033-026-12622-z

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.