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Article

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.

Circulation research - 6 Aug 2010

Dobaczewski Marcin, Bujak Marcin, Li Na, Gonzalez-Quesada Carlos, Mendoza Leonardo H, Wang Xiao-Fan, Frangogiannis Nikolaos G

Abstract excerpt

RATIONALE: Cardiac fibroblasts are key effector cells in the pathogenesis of cardiac fibrosis. Transforming growth factor (TGF)-beta/Smad3 signaling is activated in the border zone of healing infarcts and induces fibrotic remodeling of the infarcted ventricle contributing to the development of di...

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Identifiers

PMID: 20522804
DOI: 10.1161/CIRCRESAHA.109.216101
PMCID: PMC2917472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20522804-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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