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Article

PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.

Acta pharmacologica Sinica - 1 May 2026

Chen Zi-Yang, Guo Ren, Wang Min, Ji Si-Jia, Zhang Jing-Wei, Zheng Hui-Xiang, Wang Shi-Tong, Xie Xin

Abstract excerpt

Phospholamban (PLN) is a regulatory protein of the SERCA2α calcium transporter, which plays an important role in maintaining calcium homeostasis in cardiomyocytes. Deletion of the 14th arginine of PLN (PLN-R14del) leads to dysregulation of SERCA2α and PLN aggregation, and is a common cause of dilated cardiomyopathy. In this study, by using CRISPR-Cas9 gene editing technology, we constructed the PLN-R14del mouse...

Topics

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Calcium-Binding Proteins
Cardiomyopathy, Dilated
CRISPR-Cas Systems
Disease Models, Animal
Gene Editing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Therapy

Myocytes, Cardiac

Sarcoplasmic Reticulum Calcium-Transporting ATPases

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Identifiers

PMID: 41545752
DOI: 10.1038/s41401-025-01711-7
PMCID: PMC13109371

Genes

PLN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.PMID 41545752Read ↗

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