Article
Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes.
Stem cell reports - 12 Apr 2022
Jiang Youxu, Li Xiaowei, Guo Tianwei, Lu Wen-Jing, Ma Shuhong, Chang Yun, Song Yuanxiu, Zhang Siyao, Bai Rui, Wang Hongyue, Qi Man, Jiang Hongfeng, Zhang Hongjia, Lan Feng
Abstract excerpt
Phospholamban (PLN) is a key regulator that controls the function of the sarcoplasmic reticulum (SR) and is required for the regulation of cardiac contractile function. Although PLN-deficient mice demonstrated improved cardiac function, PLN loss in humans can result in dilated cardiomyopathy (DCM) or heart failure (HF). The CRISPR-Cas9 technology was used to create a PLN knockout human induced pluripotent stem...
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