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Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples

29 Jun 2022

Abstract excerpt

BACKGROUND: Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targeted therapy. To understand the technical error due to FFPE processing, a robustly characterized diploid cell line was used to create FFPE samples with four different pre-tissue processing formalin...

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PMID: 35768876
DOI: 10.1186/s13059-022-02709-8

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