Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations.

doi:10.1073/pnas.2118529119

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Article

Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2022

Laffey Kimberly G, Stiles Robert J, Ludescher Melissa J, Davis Tessa R, Khwaja Shariq S, Bram Richard J, Wettstein Peter J, Ramachandran Venkataraman, Parks Christopher A, Reyes Edwin E, Ferrer Alejandro, Canfield Jenna M, Johnson Cory E, Hammer Richard D, Gil Diana, Schrum Adam G

Abstract excerpt

During normal T cell development in mouse and human, a low-frequency population of immature CD4-CD8- double-negative (DN) thymocytes expresses early, mature αβ T cell antigen receptor (TCR). We report that these early αβ TCR+ DN (EADN) cells are DN3b-DN4 stage and require CD3δ but not major histocompatibility complex (MHC) for their generation/detection. When MHC - is present, however, EADN cells can respond to...

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Identifiers

PMID: 35767640
DOI: 10.1073/pnas.2118529119
PMCID: PMC9271211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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