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Article

Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model.

Neurobiology of disease - 1 Sept 2022

O'Hanlon Maria E, Tweedy Clare, Scialo Filippo, Bass Rosemary, Sanz Alberto, Smulders-Srinivasan Tora K

Abstract excerpt

INTRODUCTION: Mitochondrial defects have been implicated in Parkinson's disease (PD) since complex I poisons were found to cause accelerated parkinsonism in young people in the early 1980s. More evidence of mitochondrial involvement arose when many of the genes whose mutations caused inherited PD were discovered to be subcellularly localized to mitochondria or have mitochondrial functions. However, the details of...

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PMID: 35764292
DOI: 10.1016/j.nbd.2022.105803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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