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Article

Perturbations in dopamine synthesis lead to discrete physiological effects and impact oxidative stress response in Drosophila.

Journal of insect physiology - 1 Feb 2015

Hanna Marley E, Bednářová Andrea, Rakshit Kuntol, Chaudhuri Anathbandhu, O'Donnell Janis M, Krishnan Natraj

Abstract excerpt

The impact of mutations in four essential genes involved in dopamine (DA) synthesis and transport on longevity, motor behavior, and resistance to oxidative stress was monitored in Drosophila melanogaster. The fly lines used for this study were: (i) a loss of function mutation in Catecholamines up (Catsup(26)), which is a negative regulator of the rate limiting enzyme for DA synthesis, (ii) a mutant for the gene...

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Identifiers

PMID: 25585352
DOI: 10.1016/j.jinsphys.2015.01.001
PMCID: PMC4699656

Genes

GSTO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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