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Article

Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation.

PloS one - 1 Jan 2011

Koutsoudakis George, Perez-del-Pulgar Sofia, Coto-Llerena Mairene, Gonzalez Patricia, Dragun Jakub, Mensa Laura, Crespo Gonzalo, Navasa Miguel, Forns Xavier

Abstract excerpt

The introduction of the genotype 2a isolate JFH1 was a major breakthrough in the field of hepatitis C virus (HCV), allowing researchers to study the complete life cycle of the virus in cell culture. However, fully competent culture systems encompassing the most therapeutically relevant HCV genotypes are still lacking, especially for the highly drug-resistant genotype 1b. For most isolated HCV clones, efficient...

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Identifiers

PMID: 21887279
DOI: 10.1371/journal.pone.0023587
PMCID: PMC3160967

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Source receipt: pubmed, retrieved 7 Sept 2026.

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