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Article

A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2021

Zhu Ying, Tian Jianbo, Peng Xiating, Wang Xiaoyang, Yang Nan, Ying Pingting, Wang Haoxue, Li Bin, Li Yue, Zhang Ming, Cai Yimin, Lu Zequn, Niu Siyuan, Li Yao, Zhong Rong, Chang Jiang, Miao Xiaoping

Abstract excerpt

AIM: This study aimed to identify the functional genes and genetic variants associated with the prognosis of pancreatic ductal adenocarcinoma (PDAC) and reveal the mechanism underlying their prognostic roles. METHODS: First, we implement a two-stage exome-wide association study in a total of 1070 patients to identify the genetic variant correlated with PDAC prognosis. Then we performed fine mapping through...

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PMID: 33975060
DOI: 10.1016/j.ejca.2021.04.008

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