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Article

Exome Sequencing of Pancreatic Acinar Carcinoma Identified Distinctive Mutation Patterns.

Pancreas - 1 Aug 2021

Liu Yuanhang, Raimondo Massimo, Wallace Michael B, Mody Kabir, Stauffer John A, Zhang Lizhi, Ji Baoan, Bi Yan

Abstract excerpt

OBJECTIVES: Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic cancer. The advancement of treatment is hampered because of the limited knowledge of its molecular mechanism. METHODS: Whole-exome sequencing was performed on DNA extracted from 11 pure ACC surgical samples. Potential germline variants were removed on the basis of polymorphic databases, alternative allele frequency, coverage depth, and...

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PMID: 34629449
DOI: 10.1097/MPA.0000000000001870
PMCID: PMC8516064

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