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Copy Number Variations in Pancreatic Cancer: From Biological Significance to Clinical Utility

27 Dec 2023

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, characterized by high tumor heterogeneity and a poor prognosis. Inter- and intra-tumoral heterogeneity in PDAC is a major obstacle to effective PDAC treatment; therefore, it is highly desirable to explore the tumor heterogeneity and underlying mechanisms for the improvement of PDAC prognosis. Gene copy number variations (CNVs)...

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PMID: 38203561
DOI: 10.3390/ijms25010391

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