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Genomic Alterations and Their Clinical Implications in Pancreatic Ductal Adenocarcinoma in a Large-Scale Chinese Cohort.

Cancer medicine - 1 Jul 2026

Dong Mingwei, Hua Jie, Ma Zhilong, Tang Rong, Wei Miaoyan, Lv Zonglin, Liu Yuan, Chen Ke, Du Qiong, Wang Wei, Yu Xianjun, Xu Jin

Abstract excerpt

Genomic sequencing has made precision oncology of pancreatic ductal adenocarcinoma (PDAC) feasible and is recommended by numerous clinical guidelines. The clinical significance of genomic alterations in PDAC remains to be revealed. This study was designed to bridge this gap by elucidating the clinical relevance of genomic profiling in a diverse PDAC population. From January 1, 2021 to April 30, 2023, we...

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Source

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Identifiers

PMID: 42487270
DOI: 10.1002/cam4.72083
PMCID: PMC13392211

Genes

KRAS
ARID1A
ATR
BRCA1
PALB2
RAD50
RAD51D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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