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Article

Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis.

Stem cell reports - 12 Jul 2022

Hawkins Sophie, Namboori Seema C, Tariq Ammarah, Blaker Catherine, Flaxman Christine, Dey Nidhi S, Henley Peter, Randall Andrew, Rosa Alessandro, Stanton Lawrence W, Bhinge Akshay

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motor neurons (MNs). There are no effective treatments and patients usually die within 2-5 years of diagnosis. Emerging commonalities between familial and sporadic cases of this complex multifactorial disorder include disruption to RNA processing and cytoplasmic inclusion bodies containing TDP-43 and/or FUS...

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Identifiers

PMID: 35750046
DOI: 10.1016/j.stemcr.2022.05.019
PMCID: PMC9287677

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Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis.PMID 35750046Read ↗

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