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Article

How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia.

Genes - 10 Jun 2022

Kasap Merve, Dwyer Donard S

Abstract excerpt

Schizophrenia is a highly heritable polygenic psychiatric disorder. Characterization of its genetic architecture may lead to a better understanding of the overall burden of risk variants and how they determine susceptibility to disease. A major goal of this project is to develop a modeling approach to compare and quantify the relative effects of single nucleotide polymorphisms (SNPs), copy number variants (CNVs)...

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Identifiers

PMID: 35741803
DOI: 10.3390/genes13061040
PMCID: PMC9222307

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