Article
Efficient strategy for detecting gene × gene joint action and its application in schizophrenia.
Genetic epidemiology - 1 Jan 2014
Won Sungho, Kwon Min-Seok, Mattheisen Manuel, Park Suyeon, Park Changsoon, Kihara Daisuke, Cichon Sven, Ophoff Roel, Nöthen Markus M, Rietschel Marcella, Baur Max, Uitterlinden Andre G, Hofmann A, Lange Christoph
Abstract excerpt
We propose a new approach to detect gene × gene joint action in genome-wide association studies (GWASs) for case-control designs. This approach offers an exhaustive search for all two-way joint action (including, as a special case, single gene action) that is computationally feasible at the genome-wide level and has reasonable statistical power under most genetic models. We found that the presence of any gene ×...
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