Article
EBV BILF1 evolved to downregulate cell surface display of a wide range of HLA class I molecules through their cytoplasmic tail.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2013
Griffin Bryan D, Gram Anna M, Mulder Arend, Van Leeuwen Daphne, Claas Frans H J, Wang Fred, Ressing Maaike E, Wiertz Emmanuel
Abstract excerpt
Coevolution of herpesviruses and their hosts has driven the development of both host antiviral mechanisms to detect and eliminate infected cells and viral ploys to escape immune surveillance. Among the immune-evasion strategies used by the lymphocryptovirus (γ(1)-herpesvirus) EBV is the downregulation of surface HLA class I expression by the virally encoded G protein-coupled receptor BILF1, thereby impeding...
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