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Article

Past and ongoing adaptation of human cytomegalovirus to its host

8 May 2020

Abstract excerpt

Cytomegaloviruses (order Herpesvirales) display remarkable species-specificity as a result of long-term co-evolution with their mammalian hosts.Human cytomegalovirus (HCMV) is exquisitely adapted to our species and displays high genetic diversity.We leveraged information on inter-species divergence of primate-infecting cytomegaloviruses and intra-species diversity of clinical isolates to provide a genome-wide...

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PMID: 32384127
DOI: 10.1371/journal.ppat.1008476

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