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Article

Silybin suppresses ovarian cancer cell proliferation by inhibiting isocitrate dehydrogenase 1 activity.

Cancer science - 1 Sept 2022

Wei Zibo, Ye Shuangyan, Feng Haipeng, Zeng Chong, Dong Xinhuai, Zeng Xiaokang, Zeng Liming, Lin Xu, Liu Qiuzhen, Yao Jie

Abstract excerpt

Metabolic reprogramming is a sign of malignant tumors, and targeting the metabolism of tumor cells has become a promising therapeutic approach. Here, we report that Silybin (a nontoxic flavonoid commonly used for liver protection) exhibits prominent anti-tumor effects on human ovarian cancer cells. Treatment of an ovarian cancer cell line with Silybin interfered with glutamine metabolism and the tricarboxylic...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35730256
DOI: 10.1111/cas.15470
PMCID: PMC9459272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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