Article

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

2025-05-08

Abstract excerpt

As cancer cell specific rewiring of metabolic networks creates potential therapeutic opportunities, we conducted a synthetic lethal screen utilizing inhibitors of metabolic pathways. Simultaneous administration of (R)-GNE-140 and BMS-986205 (Linrodostat) preferentially halted proliferation of ovarian cancer cells, but not of their non-oncogenically transformed progenitor cells. While (R)-GNE-140 inhibits lactate d...

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Literature Corpus work: ca092983-2bbf-5172-a87c-4cab7ada9a57
DOI: 10.1101/2025.05.02.651820

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