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Article

Discovery of a Novel Chemical Scaffold Against Mutant Isocitrate Dehydrogenase 1 (IDH1).

Anticancer research - 1 Sept 2020

Kang Chung Hyo, Choi Sang Un, Son You Hwa, Lee Heung Kyoung, Jeong Hye Gwang, Yun Chang-Soo, Ahn Sunjoo, Park Chi Hoon

Abstract excerpt

BACKGROUND: Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are frequently found in various cancer types. IDH1 mutants produce 2-hydroxyglutarate (2-HG), an oncometabolite, from alpha-ketoglutarate (α-KG). This 2-HG plays a key role in tumorigenesis via inhibition of α-KG dependent enzymes. For this reason, IDH1 mutant could be an ideal target for the treatment of cancer. MATERIALS AND METHODS: To find a...

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PMID: 32878781
DOI: 10.21873/anticanres.14496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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