Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variability of Primary Sjögren's Syndrome Is Driven by Interferon‐α and Interferon‐α Blood Levels Are Associated With the Class II HLA–DQ Locus

20 Jun 2022

Abstract excerpt

OBJECTIVE: Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptomic, proteomic, cellular, and genetic data with clinical phenotypes in a cohort of 351 patients with primary SS. METHODS: We analyzed blood transcriptomes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Salivary Gland Disorders and Functions
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35726083
DOI: 10.1002/art.42265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variability of Primary Sjögren's Syndrome Is Driven by Interferon‐α and Interferon‐α Blood Levels Are Associated With the Class II HLA–DQ LocusPMID 35726083Read ↗

Interferons in Sjögren’s Syndrome: Genes, Mechanisms, and EffectsSemantic proximity Read ↗

Primary Sjogren’s Syndrome and the Type I Interferon SystemSemantic proximity Read ↗

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndromeSemantic proximity Read ↗

Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus ErythematosusSemantic proximity Read ↗

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.Semantic proximity Read ↗

Transcription profiling of peripheral B cells in antibody‐positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signatureSemantic proximity Read ↗

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome.Semantic proximity Read ↗

Deciphering the interferon gene signature spectrum: association with the clinical heterogeneity of Sjögren's disease.Semantic proximity Read ↗

Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome.Semantic proximity Read ↗

Implications of IFNγ SNP rs2069705 in primary Sjögren's syndrome: transcriptional activation and B cell infiltration.Semantic proximity Read ↗

Decades-long elevation of interferon-α drives a Sjögren disease endotype: an interdisciplinary studySemantic proximity Read ↗

Analysis of Gene Expression and TCR/B Cell Receptor Profiling of Immune Cells in Primary Sjögren’s Syndrome by Single-Cell SequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.