Article

Decades-long elevation of interferon-α drives a Sjögren disease endotype: an interdisciplinary study

2025-08-07

Abstract excerpt

<h4>SUMMARY</h4> <h4>BACKGROUND</h4> Mechanistic heterogeneity is a major obstacle to the development of effective treatment for Sjögren disease (SjD) and there is a pressing need to stratify SjD according to precision medicine principles. Aberrant activation of the type I interferon (IFN) pathway represents a leading candidate pathway, but a causal role of elevated IFN-α in driving a Sjögren disease endotype re...

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Literature Corpus work: c5c94df6-063c-51ed-802b-14648638c87c
DOI: 10.1101/2025.08.06.668845

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