Transcription profiling of peripheral B cells in antibody‐positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature

Abstract excerpt

B cells play a key role in the pathogenesis of primary Sjögren's syndrome (pSS). The aim of this study was to analyse the transcriptome of CD19+ B cells from patients with pSS and healthy controls to decipher the B cell-specific contribution to pSS. RNA from purified CD19+ B cells from 12 anti-SSA antibody-positive untreated female patients with pSS and 20 healthy blood donors was subjected to whole transcriptome...

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