Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome.

doi:10.1093/rheumatology/keaa367

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Article

Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome.

Rheumatology (Oxford, England) - 1 Feb 2021

Thorlacius Guðný Ella, Hultin-Rosenberg Lina, Sandling Johanna K, Bianchi Matteo, Imgenberg-Kreuz Juliana, Pucholt Pascal, Theander Elke, Kvarnström Marika, Forsblad-d'Elia Helena, Bucher Sara Magnusson, Norheim Katrine B, Johnsen Svein Joar Auglænd, Hammenfors Daniel, Skarstein Kathrine, Jonsson Malin V, Baecklund Eva, Aqrawi Lara A, Jensen Janicke Liaaen, Palm Øyvind, Morris Andrew P, Meadows Jennifer R S, Rantapää-Dahlqvist Solbritt, Mandl Thomas, Eriksson Per, Lind Lars, Omdal Roald, Jonsson Roland, Lindblad-Toh Kerstin, Rönnblom Lars, Wahren-Herlenius Marie, Nordmark Gunnel

Abstract excerpt

OBJECTIVES: Clinical presentation of primary Sjögren's syndrome (pSS) varies considerably. A shortage of evidence-based objective markers hinders efficient drug development and most clinical trials have failed to reach primary endpoints. METHODS: We performed a multicentre study to identify patient subgroups based on clinical, immunological and genetic features. Targeted DNA sequencing of 1853 autoimmune-related...

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PMID: 32889544
DOI: 10.1093/rheumatology/keaa367
PMCID: PMC7850528

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