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Article

Deciphering the interferon gene signature spectrum: association with the clinical heterogeneity of Sjögren's disease.

Frontiers in immunology - 1 Jan 2026

Luo Ziyue, Chen Ai, Huang Yue, Zhang Kaiyuan, Chen Muzhi, Wang Xinchang

Abstract excerpt

Purpose: This study aimed to identify interferon (IFN)-related key genes in patients with Sjögren's Disease (SjD) and to elucidate their specific associations with the heterogeneous clinical phenotypes and laboratory parameters of the disease. Methods: Bioinformatics analyses, including differentially expressed gene (DEG) screening, weighted gene co-expression network analysis (WGCNA), and machine learning, were...

Topics

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Computational Biology
Gene Expression Profiling
Gene Regulatory Networks
Interferon-Induced Helicase, IFIH1
Interferons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Sjogren's Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 41929488
DOI: 10.3389/fimmu.2026.1762625
PMCID: PMC13038951

Genes

CXCL10
IFIH1
JAK2
DDX60L
NMI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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