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Article

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

19 May 2017

Abstract excerpt

OBJECTIVES: Multiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjögren's syndrome (SS) pathology. METHODS: We generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation. RESULTS: Our...

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PMID: 28522454
DOI: 10.1136/annrheumdis-2016-210788

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