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Article

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome.

Frontiers in immunology - 1 Jan 2021

Imgenberg-Kreuz Juliana, Sandling Johanna K, Norheim Katrine Brække, Johnsen Svein Joar Auglænd, Omdal Roald, Syvänen Ann-Christine, Svenungsson Elisabet, Rönnblom Lars, Eloranta Maija-Leena, Nordmark Gunnel

Abstract excerpt

Primary Sjögren's syndrome (pSS) is an autoimmune inflammatory disease with profound clinical heterogeneity, where excessive activation of the type I interferon (IFN) system is considered one of the key mechanisms in disease pathogenesis. Here we present a DNA methylation-based IFN system activation score (DNAm IFN score) and investigate its potential associations with sub-phenotypes of pSS. The study comprised...

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Identifiers

PMID: 34335613
DOI: 10.3389/fimmu.2021.702037
PMCID: PMC8322981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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