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Article

Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.

Journal of bacteriology - 1 Jul 1990

Richardson M A, Kuhstoss S, Huber M L, Ford L, Godfrey O, Turner J R, Rao R N

Abstract excerpt

Several cosmid clones from Streptomyces ambofaciens containing the spiramycin resistance gene srmB were introduced into S. fradiae PM73, a mutant defective in tylosin synthesis, resulting in tylosin synthesis. The DNA responsible for this complementation was localized to a 10.5-kilobase EcoRI fragment. A 32-kilobase DNA segment which included the srmB spiramycin resistance gene and DNA which complemented the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 2193916
DOI: 10.1128/jb.172.7.3790-3798.1990
PMCID: PMC213357

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Source receipt: pubmed, retrieved 7 Sept 2026.

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