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Article

Organization of gene programs revealed by unsupervised analysis of diverse gene-trait associations.

Nucleic acids research - 26 Aug 2022

Mizikovsky Dalia, Naval Sanchez Marina, Nefzger Christian M, Cuellar Partida Gabriel, Palpant Nathan J

Abstract excerpt

Genome wide association studies provide statistical measures of gene-trait associations that reveal how genetic variation influences phenotypes. This study develops an unsupervised dimensionality reduction method called UnTANGLeD (Unsupervised Trait Analysis of Networks from Gene Level Data) which organizes 16,849 genes into discrete gene programs by measuring the statistical association between genetic variants...

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Identifiers

PMID: 35716123
DOI: 10.1093/nar/gkac413
PMCID: PMC9410900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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