Article

Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens

2023-02-22

Abstract excerpt

CRISPR-Cas9 screens facilitate the discovery of gene functional relationships and phenotype-specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole-genome CRISPR screens aimed at identifying cancer-specific genetic dependencies across human cell lines. A mitochondria-associated bias has been previously reported to mask signals for genes involved in other functions, and thus, me...

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Literature Corpus work: d265be74-ee13-5af5-bb15-4365bc4f2f8d
DOI: 10.1101/2023.02.22.529573

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