Article
Role of genetic modifiers on pulmonary consequences of cancer therapy in children.
Scientific reports - 2 May 2025
Dobkin Shoshana Leftin, Chang Xiao, Mentch Frank, Hakonarson Hakon
Abstract excerpt
Childhood cancer survivors (CCS) often face late-onset adverse effects, with pulmonary complications being particularly common. In this study, we analyzed 104 CCS with pulmonary issues post-treatment using a genome-wide association study (GWAS) to identify genetic susceptibility markers. Among the cohort, 20% were diagnosed with interstitial lung disease (ILD), while other complications included pulmonary...
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