Outcomes of pediatric cancer predisposition syndromes identified by phenotype directed recognition: an Indian cohort

Abstract excerpt

<title>Abstract</title> <p>Background Cancer predisposition syndromes (CPS) are implicated in 8–10% of childhood cancers in large prospective studies. Early recognition informs therapy, reduces treatment-related toxicity, and enables surveillance and family-level interventions. In low- and middle-income countries (LMICs), universal germline sequencing is seldom feasible, and phenotype-directed testing is the most...

Topics

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• Child
• Cohort Studies
• Disease Susceptibility
• Genetic Predisposition to Disease
• Genetic Testing
• Genotype
• Neoplasms
• Neurofibromatosis 1

Identifiers and source

Literature Corpus work

d85e33dc-47bc-509c-ab51-1f3ad9f72408

DOI

10.21203/rs.3.rs-7723362/v1