Article

Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteome

2026-01-17

Abstract excerpt

Chronic Kidney Disease (CKD) is a complex polygenic disease. We performed genome-wide association meta-analyses of four CKD-defining traits in up to 890,000 individuals and identified 508 loci associated with at least one trait, including 237 multi-trait CKD loci. Colocalization with kidney mRNAs, proteins and methylation patterns prioritized 651 CKD kidney genes (including 330 novel candidates) at 320 CKD-definin...

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Literature Corpus work: 86e3c444-5164-5082-b178-08711e0af5d5
DOI: 10.64898/2026.01.15.26344229

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