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Article

Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models.

Disease models & mechanisms - 1 Jun 2025

Sakakibara Kenji, Tanaka Kenjiro, Iida Madoka, Imai Yuta, Okada Mai, Sahashi Kentaro, Hirunagi Tomoki, Maeda Kentaro, Kato Ryuji, Katsuno Masahisa

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by CAG trinucleotide expansion in the androgen receptor (AR) gene. To improve the quality of in vitro cell-based assays for the evaluation of potential drug candidates for SBMA, we developed a morphology-based phenotypic analysis for a muscle cell model of SBMA that involves multiparametric morphological profiling to quantitatively...

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Identifiers

PMID: 40474744
DOI: 10.1242/dmm.052220
PMCID: PMC12233066

Genes

AR

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