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Hereditary Hemochromatosis Variant Associations with Incident Nonliver Malignancies: 11-Year Follow-up in UK Biobank.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 2 Sept 2022

Atkins Janice L, Pilling Luke C, Torti Suzy V, Torti Frank M, Kuchel George A, Melzer David

Abstract excerpt

BACKGROUND: In European ancestry populations, iron overload disorder hereditary hemochromatosis is predominantly caused by HFE p.C282Y and p.H63D mutations. Male p.C282Y homozygotes have markedly increased hepatic malignancy incidence, but risks for other cancers in male and female homozygotes are unclear. METHODS: 451,143 UK Biobank European ancestry participants (aged 40-70 years; 54.3% female) were followed...

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PMID: 35709753
DOI: 10.1158/1055-9965.EPI-22-0284
PMCID: PMC9444929

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