Article
Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients.
International journal of cancer - 15 Jan 2006
Syrjäkoski Kirsi, Fredriksson Henna, Ikonen Tarja, Kuukasjärvi Tuula, Autio Ville, Matikainen Mika P, Tammela Teuvo L J, Koivisto Pasi A, Schleutker Johanna
Abstract excerpt
Hereditary hemochromatosis (HH), the most common genetic disease in northern Europeans, is an autosomal recessive disorder of iron metabolism. The association between hepatocellular carcinoma and HFE homozygosity is well documented, but recently HFE hetero- and homozygosity has also been linked to nonhepatocellular malignancies, including female breast cancer. We hypothesized that C282Y and H63D mutations in the...
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