Article
Targeted resequencing analysis of 31 genes commonly mutated in myeloid disorders in serial samples from myelodysplastic syndrome patients showing disease progression
20 May 2015
Abstract excerpt
The myelodysplastic syndromes (MDS) are clonal disorders of the hematopoietic stem cell, characterized by ineffective hematopoiesis and peripheral blood cytopenias, and patients typically have a hypercellular bone marrow. Approximately 30–40% of patients undergo leukemic transformation to acute myeloid leukemia (AML) during the course of their disease. 1 Several recurrent gene mutations have been identified in...
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