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Article

Computational analysis for the determination of deleterious nsSNPs in human MTHFR gene.

Computational biology and chemistry - 1 Jun 2018

Desai Mansi, Chauhan J B

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and plays a central role in DNA methylation and biosynthesis. MTHFR mutations may alter the cellular folate supply which in turn affects nucleic acid synthesis, DNA methylation and chromosomal damage. The identification of number of SNPs in the human genome growing nowadays and hence, the evaluation of functional &...

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Identifiers

PMID: 29524840
DOI: 10.1016/j.compbiolchem.2018.02.022

Genes

MTHFR

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