Article
In Silico Approach to Investigate the Structural and Functional Attributes of Familial Hypercholesterolemia Variants Reported in the Saudi Population.
Journal of computational biology : a journal of computational molecular cell biology - 1 Feb 2018
Morad Fatima A, Rashidi Omran M, Sadath Saida S, Al-Allaf Faisal A, Athar Mohammad, Alama Mohamed N, Edris Sherif E, Bondagji Nabeel S, Shaik Noor A, Banaganapalli Babajan, Awan Zuhier
Abstract excerpt
Familial hypercholesterolemia (FH) is a metabolic disorder that leads primarily to premature cardiovascular diseases, the main cause of mortality in Saudi Arabia (SA). FH is underreported and underdiagnosed in SA with statistical evidence of high expected prevalence in such a consanguineous community. Lacking knowledge of which and how these alterations are actually impacting lipid metabolism is one of the main...
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