Article
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Nature neuroscience - 1 Sept 2013
Burchell Victoria S, Nelson David E, Sanchez-Martinez Alvaro, Delgado-Camprubi Marta, Ivatt Rachael M, Pogson Joe H, Randle Suzanne J, Wray Selina, Lewis Patrick A, Houlden Henry, Abramov Andrey Y, Hardy John, Wood Nicholas W, Whitworth Alexander J, Laman Heike, Plun-Favreau Helene
Abstract excerpt
Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box domain-containing protein Fbxo7 (encoded by PARK15) also cause early-onset autosomal recessive Parkinson's disease, by an unknown mechanism. Here we show that Fbxo7 participates in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.