Article
F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
Human molecular genetics - 15 Nov 2015
Zhou Zhi Dong, Xie Shao Ping, Sathiyamoorthy Sushmitha, Saw Wuan Ting, Sing Tan Ye, Ng Shin Hui, Chua Heidi Pek Hup, Tang Alyssa Mei Yan, Shaffra Fathima, Li Zeng, Wang Hongyan, Ho Patrick Ghim Hoe, Lai Mitchell Kim Peng, Angeles Dario C, Lim Tit Meng, Tan Eng-King
Abstract excerpt
The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated with a severe form of autosomal recessive juvenile-onset Parkinson's disease (PD) (PARK 15). Here we demonstrated that wild-type (WT) FBXO7 is a stress response protein and it can play both cytoprotective and neurotoxic roles. The WT FBXO7 protein is vital to cell mitophagy and can facilitate mitophagy to protect cells, whereas...
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