Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

14 Dec 2019

Abstract excerpt

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the loss of nigrostriatal dopamine neurons. PARK2 mutations cause early-onset Parkinson's disease (EO-PD). PARK2 encodes an E3 ubiquitin ligase, Parkin. Extensive in vitro studies and cell line characterization have shown that Parkin is required for mitophagy, but the physiological pathology and context of the pathway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31846738
DOI: 10.1016/j.nbd.2019.104717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged micePMID 31846738Read ↗

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome RecruitmentSemantic proximity Read ↗

Lack of Parkin Anticipates the Phenotype and Affects Mitochondrial Morphology and mtDNA Levels in a Mouse Model of Parkinson's Disease.Semantic proximity Read ↗

Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.Semantic proximity Read ↗

Parkin: a potential target to promote healthy ageingSemantic proximity Read ↗

Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches.Semantic proximity Read ↗

Mitophagy in Parkinson’s Disease: From Pathogenesis to TreatmentSemantic proximity Read ↗

Defective PTEN-induced kinase 1/Parkin mediated mitophagy and neurodegenerative diseasesSemantic proximity Read ↗

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons.Semantic proximity Read ↗

Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo.Semantic proximity Read ↗

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease.Semantic proximity Read ↗

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesisSemantic proximity Read ↗

Pathologic and therapeutic implications for the cell biology of parkin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.