Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C ) mice.

Journal of cellular and molecular medicine - 1 Jul 2022

Blank Martha, McGregor Narelle E, Rowley Lynn, Kung Louise H W, Crimeen-Irwin Blessing, Poulton Ingrid J, Walker Emma C, Gooi Jonathan H, Lamandé Shireen R, Sims Natalie A, Bateman John F

Abstract excerpt

The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix. This causes intracellular endoplasmic reticulum (ER) retention of the misfolded collagen and can result in a pathological ER stress response. A therapeutic approach to reduce this toxic mutant load could be to stimulate mutant collagen degradation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbamazepine
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I

Share to Disease Models, Animal

Share to Osteogenesis

Share to Osteogenesis Imperfecta

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 35701367
DOI: 10.1111/jcmm.17437
PMCID: PMC9279589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C ) mice.PMID 35701367Read ↗

The effect of carbamazepine on bone structure and strength in control and Osteogenesis Imperfecta ( <i>Col1a2</i> <sup> +/ <i>p.G610C</i> </sup> ) miceSemantic proximity Read ↗

Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Semantic proximity Read ↗

Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.Semantic proximity Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

Carbamazepine reduces disease severity in a mouse model of metaphyseal chondrodysplasia type Schmid caused by a premature stop codon (Y632X) in the Col10a1 gene.Semantic proximity Read ↗

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.Semantic proximity Read ↗

Exploration of the skeletal phenotype of the Col1a1 +/Mov13 mouse model for haploinsufficient osteogenesis imperfecta type 1.Semantic proximity Read ↗

Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta.Semantic proximity Read ↗

4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta.Semantic proximity Read ↗

Severely Impaired Bone Material Quality in Chihuahua Zebrafish Resembles Classical Dominant Human Osteogenesis Imperfecta.Semantic proximity Read ↗

Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta.Semantic proximity Read ↗

Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.