Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta.

Bone - 1 Sept 2016

Jacobsen Christina M, Schwartz Marissa A, Roberts Heather J, Lim Kyung-Eun, Spevak Lyudmila, Boskey Adele L, Zurakowski David, Robling Alexander G, Warman Matthew L

Abstract excerpt

Osteogenesis Imperfecta (OI) comprises a group of genetic skeletal fragility disorders. The mildest form of OI, Osteogenesis Imperfecta type I, is frequently caused by haploinsufficiency mutations in COL1A1, the gene encoding the α1(I) chain of type 1 collagen. Children with OI type I have a 95-fold higher fracture rate compared to unaffected children. Therapies for OI type I in the pediatric population are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Calcification, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type I, alpha 1 Chain

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Lumbar Vertebrae

Share to Osteogenesis Imperfecta

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 27297606
DOI: 10.1016/j.bone.2016.06.005
PMCID: PMC4985001

Genes

HBM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta.PMID 27297606Read ↗

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis ImperfectaSemantic proximity Read ↗

Exploration of the skeletal phenotype of the Col1a1 +/Mov13 mouse model for haploinsufficient osteogenesis imperfecta type 1.Semantic proximity Read ↗

Mutations in WNT1 are a cause of osteogenesis imperfectaSemantic proximity Read ↗

The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XVSemantic proximity Read ↗

Pleotropic effects of a recessive C <i>OL1α2</i> mutation occurring in a mouse model of severe osteogenesis imperfectaSemantic proximity Read ↗

Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.Semantic proximity Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta.Semantic proximity Read ↗

Mice Carrying a Ubiquitous R235W Mutation of Wnt1 Display a Bone-Specific Phenotype.Semantic proximity Read ↗

Mutations in WNT1 cause different forms of bone fragility.Semantic proximity Read ↗

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.Semantic proximity Read ↗

AAV-based gene editing of type 1 collagen mutation to treat osteogenesis imperfectaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.