Article
Exploration of the skeletal phenotype of the Col1a1 +/Mov13 mouse model for haploinsufficient osteogenesis imperfecta type 1.
Frontiers in endocrinology - 1 Jan 2023
Claeys Lauria, Zhytnik Lidiia, Wisse Lisanne E, van Essen Huib W, Eekhoff E Marelise W, Pals Gerard, Bravenboer Nathalie, Micha Dimitra
Abstract excerpt
Introduction: Osteogenesis Imperfecta is a rare genetic connective tissue disorder, characterized by skeletal dysplasia and fragile bones. Currently only two mouse models have been reported for haploinsufficient (HI) mild Osteogenesis Imperfecta (OI); the Col1a1 +/Mov13 (Mov13) and the Col1a1 +/-365 mouse model. The Mov13 mice were created by random insertion of the Mouse Moloney leukemia virus in the first...
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