Article
Severely Impaired Bone Material Quality in Chihuahua Zebrafish Resembles Classical Dominant Human Osteogenesis Imperfecta.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2018
Fiedler Imke A K, Schmidt Felix N, Wölfel Eva M, Plumeyer Christine, Milovanovic Petar, Gioia Roberta, Tonelli Francesca, Bale Hrishikesh A, Jähn Katharina, Besio Roberta, Forlino Antonella, Busse Björn
Abstract excerpt
Excessive skeletal deformations and brittle fractures in the vast majority of patients suffering from osteogenesis imperfecta (OI) are a result of substantially reduced bone quality. Because the mechanical competence of bone is dependent on the tissue characteristics at small length scales, it is of crucial importance to assess how OI manifests at the micro- and nanoscale of bone. In this context, the Chihuahua...
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