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Mitochondrial genome mutations and neuronal dysfunction of induced pluripotent stem cells derived from patients with Alzheimer's disease.

Cell proliferation - 1 Jul 2022

Lee Yeonmi, Kim Minchul, Lee Miju, So Seongjun, Kang Soon-Suk, Choi Jiwan, Kim Deokhoon, Heo Hyohoon, Lee Sung Soo, Park Hee Ra, Ko Jung Jae, Song Jihwan, Kang Eunju

Abstract excerpt

OBJECTIVES: Patient-derived induced pluripotent stem cells (iPSCs) are materials that can be used for autologous stem cell therapy. We screened mtDNA mutations in iPSCs and iPSC-derived neuronal cells from patients with Alzheimer's disease (AD). Also, we investigated whether the mutations could affect mitochondrial function and deposition of β-amyloid (Aβ) in differentiated neuronal cells. MATERIALS AND METHODS:...

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Identifiers

PMID: 35698260
DOI: 10.1111/cpr.13274
PMCID: PMC9251050

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