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Article

Mitochondrial dynamics and bioenergetics in Alzheimer's induced pluripotent stem cell-derived neurons.

Brain : a journal of neurology - 3 Apr 2025

MacMullen Courtney, Sharma Neelam, Davis Ronald L

Abstract excerpt

Mitochondrial dysfunction is a hallmark of Alzheimer's disease, but the scope and severity of these specific deficits across forms of Alzheimer's disease are not well characterized. We designed a high-throughput longitudinal phenotypic assay to track mitochondrial dynamics and bioenergetics in glutamatergic induced pluripotent stem cell (iPSC)-derived human neurons possessing mutations in presenilin 1 (PSEN1),...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Induced Pluripotent Stem Cells
Energy Metabolism
Neurons
Presenilin-1
Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mitochondrial Dynamics

Mitochondria

Presenilin-2

Mutation

Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 39513728
DOI: 10.1093/brain/awae364
PMCID: PMC12168126

Genes

APP
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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